Welcome to the future of skincare. In 2026, PDRN (Polydeoxyribonucleotide) has transitioned from exclusive clinical injectables to the must-have topical ingredient in every high-performance Korean beauty routine. Often referred to as "Salmon DNA," PDRN works by mimicking the body’s own DNA to trigger rapid cellular repair, boost collagen, and restore a resilient "glass skin" glow.
What is PDRN?
PDRN is a low-molecular-weight DNA fragment typically extracted from salmon sperm cells. This source is used because salmon DNA shares a high structural similarity with human DNA, making it remarkably biocompatible and safe for human tissue. By 2026, innovative vegan PDRN (plant-based) alternatives derived from ginseng or yeast have also entered the market to cater to eco-conscious consumers.
Key Beauty Benefits
PDRN does not just mask imperfections; it communicates with your cells to actively rebuild the skin's foundation.
- Cellular Regeneration: PDRN activates the A2A adenosine receptors, which trigger a "wound healing cascade". This speeds up the repair of micro-damage from UV rays, pollution, and aging.
- Collagen & Elastin Boost: It stimulates fibroblasts (the skin's factory cells) to increase collagen production by up to 25–35%. This results in firmer, more elastic skin with a visible reduction in fine lines.
- Intensive Barrier Repair: PDRN strengthens the skin’s lipid barrier and enhances "barrier intelligence," helping the skin stay hydrated and resist environmental irritants.
- Post-Treatment Recovery: It is the "gold standard" for post-procedure care, significantly reducing redness and downtime after laser treatments, chemical peels, or microneedling.
- Brightening & Tone Correction: By inhibiting melanin production and promoting healthy cell turnover, PDRN fades acne marks and sunspots to create a clear "glass skin" effect.
Brand Descriptions & Product Highlights
1. Dr. Althea PDRN Reju 5000 Cream (20g)
- Product Details: A biotech-powered recovery cream with a lightweight jelly texture that strengthens the skin barrier and provides SOS relief.
- Key Ingredients: 5,000ppm Vegan PDRN (probiotic-derived), 50,000ppm Centella Asiatica, Panthenol, rhEGF, and Multi-Hyaluronic Acid.
- How to Use: Apply a small amount to dry or irritated areas after cleansing and toning. Can also be used as an overnight sleeping mask.
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2. Anua PDRN Hyaluronic Acid 100 Moisturizing Cream (60ml)
- Product Details: An emerald-tinted, lightweight moisturizer designed for 100-hour deep hydration and a radiant "glass skin" finish.
- Key Ingredients: Salmon PDRN, 10 types of Hyaluronic Acid, and Hydrolyzed Collagen.
- How to Use: Massage into the skin daily (AM/PM) as the final step of your routine.
To purchase Anua PDRN Hyaluronic Acid 100 Moisturizing Cream 60ml [CLICK], Scalp Defense with lowest price, please click the button below.
3. Rejuveon PDRN 1000 Plus Cream (20g)
- Product Details: An intensive repair cream with 99.99% high-purity PDRN, ideal for post-laser or microneedling care.
- Key Ingredients: 1,000ppm PDRN, Peptides, Exosomes, Niacinamide, and Ceramides.
- How to Use: Apply a pea-sized amount evenly to face and neck morning and night.
4. REJUCHIOL PDRN 1500ppm Perfect Cream (30ml)
- Product Details: Known as a "Liquid Bandage," this cream delivers high-potency regeneration and a "Rejuran Glow".
- Key Ingredients: 1,500ppm PDRN, Bakuchiol (gentle retinol alternative), Glutathione, and Triple Peptide Complex.
- How to Use: Press the cream into the skin with palms; the warmth helps the PDRN absorb deeper.
To purchase REJUCHIOL PDRN 1500ppm Cream 30ml [CLICK], Scalp Defense with lowest price, please click the button below.
5. REJURAN Healer Skin Protection Mask (5 packs/box)
- Product Details: A premium microfiber mask that delivers a high dose of c-PDRN to soothe stressed skin and enhance elasticity.
- Key Ingredients: c-PDRN (marine-based DNA), Panthenol, Allantoin, and Centella Asiatica.
- How to Use: Apply to clean skin for 10–20 minutes. Pat remaining essence into the skin—do not rinse.
To purchase REJURAN Healer Skin Protection Mask (5 packs/box) [CLICK], Scalp Defense with lowest price, please click the button below.
6. Dr. Reju-All PD3 Advanced PDRN Rejuvenating Cream (20ml)
- Product Details: A non-sticky gel cream featuring uniform micro-sized DNA particles for superior penetration.
- Key Ingredients: 1,200ppm 99% pure Salmon PDRN, 20,000ppm Niacinamide, and 20,000ppm Panthenol.
- How to Use: Use as the final step of your nighttime routine for maximum overnight rejuvenation.
To purchase Dr. Reju-All PD3 Advanced PDRN Rejuvenating Cream 20ml [CLICK], Scalp Defense with lowest price, please click the button below.
7. VT Cosmetics PDRN Capsule Cream 100 (50ml)
- Product Details: A high-moisture capsule cream that combines Salmon PDRN with lipids to strengthen the skin from within.
- Key Ingredients: 100,000ppm Salmon PDRN Liposomes, Ceramides, and Squalane.
- How to Use: Apply a moderate amount and gently massage until the capsules melt into the skin.
To purchase VT cosmetics PDRN Capsule Cream 100 50ml [CLICK] , Scalp Defense with lowest price, please click the button below.
8. Rejuran Turnover Anti-Aging Active Cream (50ml)
- Product Details: A richer "Skin Repair Activator" that restores the skin’s natural turnover cycle for firmer, younger-looking skin.
- Key Ingredients: c-PDRN and the Pure Organic Nourishing Complex.
- How to Use: Apply daily to clean skin, focusing on areas with fine lines or loss of elasticity.
To purchase Rejuran Turnover Anti-Aging Active Cream (50ml) [CLICK], Scalp Defense with lowest price, please click the button below.
Related Questions (FAQ)
Yes. In 2026 routines, PDRN is often used in the evening to repair skin while Vitamin C provides antioxidant protection during the day. It is also highly compatible with Bakuchiol.
PDRN is naturally anti-inflammatory and biocompatible, making it excellent for sensitive, irritated, or post-procedure skin.
Hydration and barrier improvement are often seen in 1–2 weeks, while visible firmness and fine line reduction typically occur by weeks 8–12.
